Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50436552 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_966838 (CHEMBL2400839) |
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Ki | 93±n/a nM |
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Citation | Fransson, R; Sköld, C; Kratz, JM; Svensson, R; Artursson, P; Nyberg, F; Hallberg, M; Sandström, A Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability. J Med Chem56:4953-65 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46371.54 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor. |
Residue: | 407 |
Sequence: | MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH
KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTIST
VVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
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BDBM50436552 |
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n/a |
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Name | BDBM50436552 |
Synonyms: | CHEMBL2397489 |
Type | Small organic molecule |
Emp. Form. | C20H23N3O2 |
Mol. Mass. | 337.4155 |
SMILES | N[C@@H](Cc1ccccc1)C(=O)N1CC[C@@H]([C@@H]1C(N)=O)c1ccccc1 |r| |
Structure |
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