| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP |
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| Ligand | BDBM50388975 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_971508 (CHEMBL2406570) |
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| Ki | 260±n/a nM |
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| Citation |  Ardecky, RJ; Welsh, K; Finlay, D; Lee, PS; González-López, M; Ganji, SR; Ravanan, P; Mace, PD; Riedl, SJ; Vuori, K; Reed, JC; Cosford, ND Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. Bioorg Med Chem Lett23:4253-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase XIAP |
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| Name: | E3 ubiquitin-protein ligase XIAP |
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| Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 56685.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170 |
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| Residue: | 497 |
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| Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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| BDBM50388975 |
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| n/a |
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| Name | BDBM50388975 |
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| Synonyms: | CHEMBL2063869 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N6O3S |
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| Mol. Mass. | 498.641 |
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| SMILES | CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)Nc1snnc1-c1ccccc1 |r| |
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| Structure | 
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