| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP |
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| Ligand | BDBM44289 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_971508 (CHEMBL2406570) |
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| Ki | 40150±n/a nM |
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| Citation |  Ardecky, RJ; Welsh, K; Finlay, D; Lee, PS; González-López, M; Ganji, SR; Ravanan, P; Mace, PD; Riedl, SJ; Vuori, K; Reed, JC; Cosford, ND Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. Bioorg Med Chem Lett23:4253-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase XIAP |
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| Name: | E3 ubiquitin-protein ligase XIAP |
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| Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 56685.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170 |
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| Residue: | 497 |
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| Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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| BDBM44289 |
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| n/a |
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| Name | BDBM44289 |
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| Synonyms: | (2S)-2-[[(2S)-2-amino-1-oxopropyl]amino]-3-methyl-N-[(2S)-1-(1-naphthalenylamino)-1-oxopropan-2-yl]butanamide;formic acid | (2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methyl-N-[(2S)-1-(naphthalen-1-ylamino)-1-oxopropan-2-yl]butanamide;formic acid | (2S)-2-[[(2S)-2-aminopropanoyl]amino]-N-[(1S)-2-keto-1-methyl-2-(1-naphthylamino)ethyl]-3-methyl-butyramide;formic acid | (2S)-2-[[(2S)-2-azanylpropanoyl]amino]-3-methyl-N-[(2S)-1-(naphthalen-1-ylamino)-1-oxidanylidene-propan-2-yl]butanamide;methanoic acid | CHEMBL1617615 | MLS-0412114.0001 | cid_44176346 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N4O3 |
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| Mol. Mass. | 384.472 |
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| SMILES | CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](C)C(=O)Nc1cccc2ccccc12 |
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| Structure | 
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