| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
|---|
| Ligand | BDBM50153713 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_973760 (CHEMBL2412043) |
|---|
| IC50 | 80±n/a nM |
|---|
| Citation |  Jansson, AM; Wieckowska, A; Björkelid, C; Yahiaoui, S; Sooriyaarachchi, S; Lindh, M; Bergfors, T; Dharavath, S; Desroses, M; Suresh, S; Andaloussi, M; Nikhil, R; Sreevalli, S; Srinivasa, BR; Larhed, M; Jones, TA; Karlén, A; Mowbray, SL DXR inhibition by potent mono- and disubstituted fosmidomycin analogues. J Med Chem56:6190-9 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
|---|
| Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
|---|
| Synonyms: | DXR_MYCTU | dxr |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42846.92 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | ChEMBL_1474510 |
|---|
| Residue: | 413 |
|---|
| Sequence: | MTNSTDGRADGRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQ
TGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTG
ARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGP
FRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVV
VHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEP
LDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQ
WAVEPATVDDVLDAQRWARERAQRAVSGMASVAIASTAKPGAAGRHASTLERS
|
|
|
|---|
| BDBM50153713 |
|---|
| n/a |
|---|
| Name | BDBM50153713 |
|---|
| Synonyms: | 3-(N-hydroxyformamido)propylphosphonic acid | 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID | CHEMBL203125 | [3-(Formyl-hydroxy-amino)-propyl]-phosphonic acid | fosmidomycin |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C4H10NO5P |
|---|
| Mol. Mass. | 183.0997 |
|---|
| SMILES | ON(CCCP(O)(O)=O)C=O |
|---|
| Structure | 
|
|---|
Search and Browse
