| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM7939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_978590 (CHEMBL2422107) |
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| Ki | 150000±n/a nM |
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| Citation |  Ramsbeck, D; Buchholz, M; Koch, B; Böhme, L; Hoffmann, T; Demuth, HU; Heiser, U Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold. J Med Chem56:6613-25 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM7939 |
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| n/a |
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| Name | BDBM7939 |
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| Synonyms: | 1H-1,3-benzodiazole | Benzimidazole | Benzimidazole (Blm) | US9138393, Benzimidazole | US9144538, Benzimidazole |
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| Type | Small organic molecule |
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| Emp. Form. | C7H6N2 |
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| Mol. Mass. | 118.1359 |
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| SMILES | c1nc2ccccc2[nH]1 |
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| Structure | 
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