| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-activated inward rectifier potassium channel 1 |
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| Ligand | BDBM50115223 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_980168 (CHEMBL2424002) |
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| EC50 | 1400±n/a nM |
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| Citation |  Ramos-Hunter, SJ; Engers, DW; Kaufmann, K; Du, Y; Lindsley, CW; Weaver, CD; Sulikowski, GA Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Bioorg Med Chem Lett23:5195-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-activated inward rectifier potassium channel 1 |
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| Name: | G protein-activated inward rectifier potassium channel 1 |
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| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56610.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107915 |
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| Residue: | 501 |
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| Sequence: | MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL
GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY
TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM
FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE
GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE
GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE
QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS
STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG
AARMEGNLPAKLRKMNSDRFT
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| BDBM50115223 |
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| n/a |
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| Name | BDBM50115223 |
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| Synonyms: | 1-(5-Methyl-2-phenyl-2H-pyrazol-3-yl)-3-phenyl-urea | CHEMBL86962 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N4O |
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| Mol. Mass. | 292.3351 |
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| SMILES | Cc1cc(NC(=O)Nc2ccccc2)n(n1)-c1ccccc1 |
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| Structure | 
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