| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Ligand | BDBM50439468 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_978758 (CHEMBL2423001) |
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| IC50 | 8350±n/a nM |
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| Citation |  Mellini, P; Kokkola, T; Suuronen, T; Salo, HS; Tolvanen, L; Mai, A; Lahtela-Kakkonen, M; Jarho, EM Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells. J Med Chem56:6681-95 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Synonyms: | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3 |
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| Type: | Protein |
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| Mol. Mass.: | 43582.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NTG7 |
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| Residue: | 399 |
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| Sequence: | MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
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| BDBM50439468 |
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| n/a |
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| Name | BDBM50439468 |
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| Synonyms: | CHEMBL2417682 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N3O5S |
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| Mol. Mass. | 485.596 |
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| SMILES | COc1ccc(cc1)C(=O)CNC(=O)[C@H](CCCCNC(C)=S)NC(=O)OCc1ccccc1 |r| |
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| Structure | 
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