| Reaction Details |
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 | Report a problem with these data |
| Target | Deoxycytidine kinase |
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| Ligand | BDBM50440158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_981695 (CHEMBL2429677) |
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| IC50 | 3201±n/a nM |
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| Citation |  Murphy, JM; Armijo, AL; Nomme, J; Lee, CH; Smith, QA; Li, Z; Campbell, DO; Liao, HI; Nathanson, DA; Austin, WR; Lee, JT; Darvish, R; Wei, L; Wang, J; Su, Y; Damoiseaux, R; Sadeghi, S; Phelps, ME; Herschman, HR; Czernin, J; Alexandrova, AN; Jung, ME; Lavie, A; Radu, CG Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem56:6696-708 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Deoxycytidine kinase |
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| Name: | Deoxycytidine kinase |
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| Synonyms: | DCK_MOUSE | Dck |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30361.42 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_981695 |
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| Residue: | 260 |
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| Sequence: | MATPPKRFCPSPSTSSEGTRIKKISIEGNIAAGKSTFVNILKQASEDWEVVPEPVARWCN
VQSTQEEFEELTTSQKSGGNVLQMMYEKPERWSFTFQSYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNSQFGQSLELDGIIYLRA
TPEKCLNRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTSFDYLQEVPVLTLDVNE
DFKDKHESLVEKVKEFLSTL
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| BDBM50440158 |
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| n/a |
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| Name | BDBM50440158 |
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| Synonyms: | CHEMBL2426595 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17FN6OS2 |
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| Mol. Mass. | 392.474 |
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| SMILES | Cc1ccc(cc1OCCF)-c1nc(CSc2nc(N)nc(N)n2)cs1 |
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| Structure | 
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