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TargetDeoxycytidine kinase
LigandBDBM50440174
Substrate/Competitorn/a
Meas. Tech.ChEMBL_981694
IC50 2.9±n/a nM
Citation Murphy JMArmijo ALNomme JLee CHSmith QALi ZCampbell DOLiao HINathanson DAAustin WRLee JTDarvish RWei LWang JSu YDamoiseaux RSadeghi SPhelps MEHerschman HRCzernin JAlexandrova ANJung MELavie ARadu CG Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem 56:6696-708 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Deoxycytidine kinase
Name:Deoxycytidine kinase
Synonyms:dCK
Type:PROTEIN
Mol. Mass.:30510.65
Organism:Homo sapiens (Human)
Description:ChEMBL_1437135
Residue:260
Sequence:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL
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  Blast E-value cutoff:
BDBM50440174
n/a
NameBDBM50440174
Synonyms:CHEMBL2426572
TypeSmall organic molecule
Emp. Form.C21H27N5O3S2
Mol. Mass.461.601
SMILESCCCc1sc(nc1CSc1nc(N)cc(N)n1)-c1ccc(OC)c(OCC(C)O)c1
Structure
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