| Reaction Details |
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 | Report a problem with these data |
| Target | RecQ-like DNA helicase BLM |
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| Ligand | BDBM50440528 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_983202 (CHEMBL2428261) |
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| IC50 | 910±n/a nM |
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| Citation |  Rosenthal, AS; Dexheimer, TS; Gileadi, O; Nguyen, GH; Chu, WK; Hickson, ID; Jadhav, A; Simeonov, A; Maloney, DJ Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorg Med Chem Lett23:5660-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RecQ-like DNA helicase BLM |
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| Name: | RecQ-like DNA helicase BLM |
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| Synonyms: | BLM | BLM_HUMAN | Bloom syndrome protein | DNA helicase, RecQ-like type 2 | RECQ2 | RECQL3 | RecQ protein-like 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 159016.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103670 |
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| Residue: | 1417 |
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| Sequence: | MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVL
RNKDVNVTEDFSFSEPLPNTTNQQRVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVC
TTQNTPTVKKSRDTALKKLEFSSSPDSLSTINDWDDMDDFDTSETSKSFVTPPQSHFVRV
STAQKSKKGKRNFFKAQLYTTNTVKTDLPPPSSESEQIDLTEEQKDDSEWLSSDVICIDD
GPIAEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHSTEKVPCIEFDDDDYDTDF
VPPSPEEIISASSSSSKCLSTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTD
CDARQISLQQQLIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLTEVDFNKSD
ASLLGSLWRYRPDSLDGPMEGDSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFS
ATRKNLFERPLFNTHLQKSFVSSNWAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASI
NDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAYQPIKEGRPIKSVSERL
SSAKTDCLPVSSTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSLSFPHTKEMMKIFH
KKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLI
VDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTL
ENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKD
ILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRE
CDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVRF
VIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHF
NNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHPDVSCDNCCKTKDYKTRDVTDD
VKSIVRFVQEHSSSQGMRNIKHVGPSGRFTMNMLVDIFLGSKSAKIQSGIFGKGSAYSRH
NAERLFKKLILDKILDEDLYINANDQAIAYVMLGNKAQTVLNGNLKVDFMETENSSSVKK
QKALVAKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVL
LQIDGVTEDKLEKYGAEVISVLQKYSEWTSPAEDSSPGISLSSSRGPGRSAAEELDEEIP
VSSHYFASKTRNERKRKKMPASQRSKRRKTASSGSKAKGGSATCRKISSKTKSSSIIGSS
SASHTSQATSGANSKLGIMAPPKPINRPFLKPSYAFS
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| BDBM50440528 |
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| n/a |
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| Name | BDBM50440528 |
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| Synonyms: | CHEMBL2426165 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9BrN6OS |
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| Mol. Mass. | 401.241 |
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| SMILES | Brc1cc(NC(=O)Nc2nnc(s2)-c2ccncc2)ccc1C#N |
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| Structure | 
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