| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN |
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| Ligand | BDBM50440527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_983201 (CHEMBL2428260) |
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| IC50 | 1100±n/a nM |
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| Citation |  Rosenthal, AS; Dexheimer, TS; Gileadi, O; Nguyen, GH; Chu, WK; Hickson, ID; Jadhav, A; Simeonov, A; Maloney, DJ Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorg Med Chem Lett23:5660-6 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN |
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| Name: | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN |
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| Synonyms: | DNA helicase, RecQ-like type 3 | Exonuclease WRN | RECQ3 | RECQL2 | RecQ protein-like 2 | WRN | WRN_HUMAN | Werner syndrome ATP-dependent helicase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 162454.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105140 |
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| Residue: | 1432 |
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| Sequence: | MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDAS
DCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVF
PQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSL
VKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAIN
KEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMII
GSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGE
DVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYK
STEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLE
NLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCL
KMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLIS
LMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADI
GITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNL
RNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQV
TGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYG
APKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKME
KYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFG
PQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSR
QLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSK
TVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSS
SQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKR
IDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMA
ITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVI
RNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEE
ICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
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| BDBM50440527 |
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| n/a |
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| Name | BDBM50440527 |
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| Synonyms: | CHEMBL2426164 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9BrN6OS |
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| Mol. Mass. | 401.241 |
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| SMILES | Brc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C#N |
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| Structure | 
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