| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 2 |
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| Ligand | BDBM50441567 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_988905 (CHEMBL2439759) |
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| IC50 | 661±n/a nM |
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| Citation |  Goodfellow, VS; Loweth, CJ; Ravula, SB; Wiemann, T; Nguyen, T; Xu, Y; Todd, DE; Sheppard, D; Pollack, S; Polesskaya, O; Marker, DF; Dewhurst, S; Gelbard, HA Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem56:8032-48 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 2 |
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| Name: | Mitogen-activated protein kinase kinase kinase 2 |
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| Synonyms: | M3K2_HUMAN | MAP3K2 | MAPK/ERK kinase kinase 2 | MAPKKK2 | MEK kinase 2 | MEKK 2 | MEKK2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69751.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473904 |
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| Residue: | 619 |
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| Sequence: | MDDQQALNSIMQDLAVLHKASRPALSLQETRKAKSSSPKKQNDVRVKFEHRGEKRILQFP
RPVKLEDLRSKAKIAFGQSMDLHYTNNELVIPLTTQDDLDKAVELLDRSIHMKSLKILLV
INGSTQATNLEPLPSLEDLDNTVFGAERKKRLSIIGPTSRDRSSPPPGYIPDELHQVARN
GSFTSINSEGEFIPESMDQMLDPLSLSSPENSGSGSCPSLDSPLDGESYPKSRMPRAQSY
PDNHQEFSDYDNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPRARRTQGTSLRSPVS
FSPTDHSLSTSSGSSIFTPEYDDSRIRRRGSDIDNPTLTVMDISPPSRSPRAPTNWRLGK
LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ
YYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIV
HRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGR
KADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVE
AKLRPSADELLRHMFVHYH
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| BDBM50441567 |
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| n/a |
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| Name | BDBM50441567 |
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| Synonyms: | CHEMBL2436978 | US10485800, Example 181 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N5 |
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| Mol. Mass. | 421.5368 |
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| SMILES | CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1 |
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| Structure | 
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