| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50441574 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_986691 (CHEMBL2438008) |
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| IC50 | >100000±n/a nM |
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| Citation |  Maingot, L; Elbakali, J; Dumont, J; Bosc, D; Cousaert, N; Urban, A; Deglane, G; Villoutreix, B; Nagase, H; Sperandio, O; Leroux, F; Deprez, B; Deprez-Poulain, R Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group. Eur J Med Chem69:244-61 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54012.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39900 |
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| Residue: | 470 |
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| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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| BDBM50441574 |
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| n/a |
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| Name | BDBM50441574 |
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| Synonyms: | CHEMBL2437163 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28ClN3O2S |
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| Mol. Mass. | 397.963 |
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| SMILES | Clc1ccc(OCC(=O)NNC(=S)NCCCCC2CCCCC2)cc1 |
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| Structure | 
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