| Reaction Details |
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 | Report a problem with these data |
| Target | Catenin beta-1/Transcription factor 7-like 2 |
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| Ligand | BDBM40314 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_987541 (CHEMBL2438919) |
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| IC50 | 300±n/a nM |
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| Citation |  Zeller, J; Turbiak, AJ; Powelson, IA; Lee, S; Sun, D; Showalter, HD; Fearon, ER Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of฿-catenin/TCF transcription. Bioorg Med Chem Lett23:5814-20 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Catenin beta-1/Transcription factor 7-like 2 |
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| Name: | Catenin beta-1/Transcription factor 7-like 2 |
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| Synonyms: | TCF4/beta-catenin |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 987541 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Transcription factor 7-like 2 |
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| Synonyms: | HMG box transcription factor 4 | T-cell factor 4 | T-cell-specific transcription factor 4 | TCF-4 | TCF4 | TCF7L2 | TF7L2_HUMAN | hTCF-4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67939.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107937 |
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| Residue: | 619 |
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| Sequence: | MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS
DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS
LSPTARTLHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSP
AHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDIS
PYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPP
HHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLY
MKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSAR
DNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPC
RRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKP
DPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSH
SSLAGTQPQPLSLVTKSLE
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| Component 2 |
| Name: | Catenin beta-1 |
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| Synonyms: | CTNB1_HUMAN | CTNNB | CTNNB1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85484.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1504364 |
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| Residue: | 781 |
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| Sequence: | MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
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| BDBM40314 |
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| n/a |
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| Name | BDBM40314 |
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| Synonyms: | 3-(4-Chloro-phenyl)-1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | 3-(4-chlorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | MLS000523518 | SMR000122591 | US9073941, 603 | cid_460749 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H10ClN5O2 |
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| Mol. Mass. | 303.704 |
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| SMILES | Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(Cl)cc1 |
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| Structure | 
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