Reaction Details |
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Target | Uridine phosphorylase 1 |
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Ligand | BDBM50026387 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1275625 (CHEMBL3090756) |
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Kd | 1200±n/a nM |
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Citation | Renck, D; Machado, P; Souto, AA; Rosado, LA; Erig, T; Campos, MM; Farias, CB; Roesler, R; Timmers, LF; de Souza, ON; Santos, DS; Basso, LA Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. J Med Chem56:8892-902 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Uridine phosphorylase 1 |
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Name: | Uridine phosphorylase 1 |
Synonyms: | UP | UPP1 | UPP1_HUMAN | UPase 1 | UrdPase 1 | Uridine phosphorylase (UPase) |
Type: | Enzyme |
Mol. Mass.: | 33939.54 |
Organism: | Homo sapiens (Human) |
Description: | Q16831 |
Residue: | 310 |
Sequence: | MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGG
SPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLH
ELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKT
DLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAY
AAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVS
YFIKKKLSKA
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BDBM50026387 |
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n/a |
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Name | BDBM50026387 |
Synonyms: | 1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE | 5-Benzyl-1-(2-hydroxy-ethoxymethyl)-1H-pyrimidine-2,4-dione | CHEMBL17432 |
Type | Small organic molecule |
Emp. Form. | C14H16N2O4 |
Mol. Mass. | 276.2878 |
SMILES | OCCOCn1cc(Cc2ccccc2)c(=O)[nH]c1=O |
Structure |
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