| Reaction Details |
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 | Report a problem with these data |
| Target | Uridine phosphorylase 1 |
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| Ligand | BDBM50443011 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1275627 (CHEMBL3090758) |
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| Kd | 4200±n/a nM |
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| Citation |  Renck, D; Machado, P; Souto, AA; Rosado, LA; Erig, T; Campos, MM; Farias, CB; Roesler, R; Timmers, LF; de Souza, ON; Santos, DS; Basso, LA Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. J Med Chem56:8892-902 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Uridine phosphorylase 1 |
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| Name: | Uridine phosphorylase 1 |
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| Synonyms: | UP | UPP1 | UPP1_HUMAN | UPase 1 | UrdPase 1 | Uridine phosphorylase (UPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 33939.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16831 |
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| Residue: | 310 |
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| Sequence: | MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGG
SPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLH
ELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKT
DLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAY
AAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVS
YFIKKKLSKA
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| BDBM50443011 |
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| n/a |
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| Name | BDBM50443011 |
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| Synonyms: | CHEMBL3087493 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H13N3O2 |
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| Mol. Mass. | 207.2291 |
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| SMILES | CN(C)Cc1c(O)[nH]c(=O)c(C#N)c1C |
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| Structure | 
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