Reaction Details |
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Target | Heat shock cognate 71 kDa protein |
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Ligand | BDBM50443575 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1279153 (CHEMBL3095088) |
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Kd | 1500±n/a nM |
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Citation | Li, X; Srinivasan, SR; Connarn, J; Ahmad, A; Young, ZT; Kabza, AM; Zuiderweg, ER; Sun, D; Gestwicki, JE Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett4:1042-7 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heat shock cognate 71 kDa protein |
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Name: | Heat shock cognate 71 kDa protein |
Synonyms: | HSC70 | HSP73 | HSP7C_HUMAN | HSPA10 | HSPA8 | heat shock 70kDa protein 8 isoform 1 | heat shock 70kDa protein 8 isoform 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 70887.67 |
Organism: | Homo sapiens (Human) |
Description: | gi_5729877 |
Residue: | 646 |
Sequence: | MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
MNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVS
SMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAA
IAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNH
FIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRA
RFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELN
KSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTI
PTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDI
DANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKN
SLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELE
KVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
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BDBM50443575 |
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n/a |
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Name | BDBM50443575 |
Synonyms: | CHEMBL3091944 |
Type | Small organic molecule |
Emp. Form. | C35H44FN6O3S3 |
Mol. Mass. | 711.955 |
SMILES | CCn1c(=O)c(sc1=Cc1cccc[n+]1CCCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)=C1Sc2cc(F)ccc2N1C |r,w:37.41,8.9| |
Structure |
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