| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
|---|
| Ligand | BDBM50443796 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1280599 (CHEMBL3096860) |
|---|
| IC50 | 3.6±n/a nM |
|---|
| Citation |  Christensen, MK; Erichsen, KD; Olesen, UH; Tjørnelund, J; Fristrup, P; Thougaard, A; Nielsen, SJ; Sehested, M; Jensen, PB; Loza, E; Kalvinsh, I; Garten, A; Kiess, W; Björkling, F Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship. J Med Chem56:9071-88 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nicotinamide phosphoribosyltransferase |
|---|
| Name: | Nicotinamide phosphoribosyltransferase |
|---|
| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55524.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P43490 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
|
|
|
|---|
| BDBM50443796 |
|---|
| n/a |
|---|
| Name | BDBM50443796 |
|---|
| Synonyms: | CHEMBL3094229 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H45N5O6S |
|---|
| Mol. Mass. | 579.752 |
|---|
| SMILES | O=C1C(NCCCCCCCS(=O)(=O)N(OCCN2CCOCC2)C2CCCCC2)C(Nc2ccncc2)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
