| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP |
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| Ligand | BDBM50443808 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1280808 (CHEMBL3097972) |
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| IC50 | 18±n/a nM |
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| Citation |  Shiokawa, Z; Hashimoto, K; Saito, B; Oguro, Y; Sumi, H; Yabuki, M; Yoshimatsu, M; Kosugi, Y; Debori, Y; Morishita, N; Dougan, DR; Snell, GP; Yoshida, S; Ishikawa, T Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells. Bioorg Med Chem21:7938-54 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase XIAP |
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| Name: | E3 ubiquitin-protein ligase XIAP |
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| Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 56685.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170 |
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| Residue: | 497 |
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| Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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| BDBM50443808 |
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| n/a |
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| Name | BDBM50443808 |
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| Synonyms: | CHEMBL3094405 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H44N6O4 |
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| Mol. Mass. | 612.7617 |
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| SMILES | CC[C@H](NC)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@@H]2Cc3cc(ccc3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc12)C#N |r| |
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| Structure | 
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