Reaction Details |
| Report a problem with these data |
Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
---|
Ligand | BDBM3032 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1278745 (CHEMBL3096292) |
---|
IC50 | 2320±n/a nM |
---|
Citation | Juvale, K; Gallus, J; Wiese, M Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2). Bioorg Med Chem21:7858-73 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Broad substrate specificity ATP-binding cassette transporter ABCG2 |
---|
Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
Mol. Mass.: | 72329.48 |
Organism: | Homo sapiens (Human) |
Description: | Q9UNQ0 |
Residue: | 655 |
Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
|
|
|
BDBM3032 |
---|
n/a |
---|
Name | BDBM3032 |
Synonyms: | CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine | PD153035 | US11001595, Compound PD153035 | US11111252, Compound PD153035 | US9422297, PD153035 |
Type | Small organic molecule |
Emp. Form. | C16H14BrN3O2 |
Mol. Mass. | 360.205 |
SMILES | COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC |
Structure |
|