| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kallikrein-1 |
|---|
| Ligand | BDBM50084637 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1278120 (CHEMBL3095808) |
|---|
| IC50 | >2000±n/a nM |
|---|
| Citation |  Lucas, SD; Gonçalves, LM; Carvalho, LA; Correia, HF; Da Costa, EM; Guedes, RA; Moreira, R; Guedes, RC Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors. J Med Chem56:9802-6 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kallikrein-1 |
|---|
| Name: | Kallikrein-1 |
|---|
| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 28874.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06870 |
|---|
| Residue: | 262 |
|---|
| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
|
|
|
|---|
| BDBM50084637 |
|---|
| n/a |
|---|
| Name | BDBM50084637 |
|---|
| Synonyms: | 2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-carbamoyl)-phenylsulfamoyl]-phenyl ester | 2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-carbamoyl)-phenylsulfamoyl]-phenyl ester(ONO-5046) | CHEMBL76688 | ONO-5046 | Sivelestat |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22N2O7S |
|---|
| Mol. Mass. | 434.463 |
|---|
| SMILES | CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc1ccccc1C(=O)NCC(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
