| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
|---|
| Ligand | BDBM50032675 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1282431 (CHEMBL3100732) |
|---|
| EC50 | 40±n/a nM |
|---|
| Citation |  Desphande, A; Xia, G; Boerma, LJ; Vines, KK; Atigadda, VR; Lobo-Ruppert, S; Grubbs, CJ; Moeinpour, FL; Smith, CD; Christov, K; Brouillette, WJ; Muccio, DD Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorg Med Chem22:178-85 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoic acid receptor RXR-alpha |
|---|
| Name: | Retinoic acid receptor RXR-alpha |
|---|
| Synonyms: | NR2B Channel Blocker | Nr2b1 | RXRA_RAT | Retinoic acid receptor RXR-alpha | Retinoid X receptor alpha | Rxra |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 51273.78 |
|---|
| Organism: | RAT |
|---|
| Description: | NR2B Channel Blocker 0 RAT::Q05343 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGSPLGSPGQLHSPISTLS
SPINGMGPPFSVISSPMGPHSMSVPTTPTLGFETGSPQLNSPMNPVSSSEDIKPPLGLNG
VLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNK
DCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKI
LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS
KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF
AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQTT
|
|
|
|---|
| BDBM50032675 |
|---|
| n/a |
|---|
| Name | BDBM50032675 |
|---|
| Synonyms: | 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid | BEXAROTENE | CHEMBL1023 | p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H28O2 |
|---|
| Mol. Mass. | 348.4779 |
|---|
| SMILES | Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
