| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50445776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1284885 (CHEMBL3108186) |
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| IC50 | 219±n/a nM |
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| Citation |  Sun, S; Zhang, Z; Kodumuru, V; Pokrovskaia, N; Fonarev, J; Jia, Q; Leung, PY; Tran, J; Ratkay, LG; McLaren, DG; Radomski, C; Chowdhury, S; Fu, J; Hubbard, B; Winther, MD; Dales, NA Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett24:520-5 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50445776 |
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| n/a |
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| Name | BDBM50445776 |
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| Synonyms: | CHEMBL3102878 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21FN4O2S |
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| Mol. Mass. | 424.491 |
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| SMILES | Cc1nc(sc1C(=O)NCc1cccc(F)c1)N1CCN(Cc2ccccc2)C1=O |
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| Structure | 
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