| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
|---|
| Ligand | BDBM50445791 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1284885 (CHEMBL3108186) |
|---|
| IC50 | 63±n/a nM |
|---|
| Citation |  Sun, S; Zhang, Z; Kodumuru, V; Pokrovskaia, N; Fonarev, J; Jia, Q; Leung, PY; Tran, J; Ratkay, LG; McLaren, DG; Radomski, C; Chowdhury, S; Fu, J; Hubbard, B; Winther, MD; Dales, NA Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett24:520-5 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stearoyl-CoA desaturase |
|---|
| Name: | Stearoyl-CoA desaturase |
|---|
| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41537.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00767 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
|
|
|
|---|
| BDBM50445791 |
|---|
| n/a |
|---|
| Name | BDBM50445791 |
|---|
| Synonyms: | CHEMBL3104822 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21N5O2S |
|---|
| Mol. Mass. | 371.457 |
|---|
| SMILES | Cc1nc(sc1C(=O)NCc1cccnc1)N1CCN(CC2CC2)C1=O |
|---|
| Structure | 
|
|---|
Search and Browse
