| Reaction Details |
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 | Report a problem with these data |
| Target | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Ligand | BDBM61867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1286129 (CHEMBL3106986) |
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| Ki | 1290±n/a nM |
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| Citation |  Brooke, DG; van Dam, EM; Watts, CK; Khoury, A; Dziadek, MA; Brooks, H; Graham, LJ; Flanagan, JU; Denny, WA Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3). Bioorg Med Chem22:1029-39 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
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| Synonyms: | 6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) | 6PF-2-K/Fru-2,6-P2ase 3 | 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme | F263_HUMAN | Fructose-2,6-bisphosphatase | PFK/FBPase 3 | PFKFB3 | Renal carcinoma antigen NY-REN-56 | iPFK-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59620.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16875 |
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| Residue: | 520 |
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| Sequence: | MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
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| BDBM61867 |
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| n/a |
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| Name | BDBM61867 |
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| Synonyms: | 2-(4-hydroxyphenyl)-5,6,7,8-tetrakis(oxidanyl)chromen-4-one | 5,6,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-1-benzopyran-4-one | 5,6,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one | 5,6,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromone | MLS000736839 | SMR000528344 | cid_96506 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10O7 |
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| Mol. Mass. | 302.2357 |
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| SMILES | Oc1ccc(cc1)-c1cc(=O)c2c(O)c(O)c(O)c(O)c2o1 |
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| Structure | 
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