| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member C3 |
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| Ligand | BDBM50446017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1283742 (CHEMBL3108467) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Flanagan, JU; Atwell, GJ; Heinrich, DM; Brooke, DG; Silva, S; Rigoreau, LJ; Trivier, E; Turnbull, AP; Raynham, T; Jamieson, SM; Denny, WA Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase (AKR1C3). Bioorg Med Chem22:967-77 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member C3 |
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| Name: | Aldo-keto reductase family 1 member C3 |
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| Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) | 3-alpha-HSD type 2 | AK1C3_HUMAN | AKR1C3 | Aldo-keto reductase family 1 member C3 | Aldo-keto reductase family 1 member C3 (AK1C3) | Aldo-keto reductase family 1 member C3 (AK1C3a) | Aldo-keto reductase family 1 member C3 (AKR1C3) | Aldo-keto-reductase family 1 member C3 | DDH1 | Dihydrodiol dehydrogenase 3 | Dihydrodiol dehydrogenase type I | Estradiol 17-beta-dehydrogenase | HSD17B5 | KIAA0119 | PGFS | Prostaglandin F synthase | Testosterone 17-beta-dehydrogenase 5 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 36859.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42330 |
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| Residue: | 323 |
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| Sequence: | MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY
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| BDBM50446017 |
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| n/a |
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| Name | BDBM50446017 |
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| Synonyms: | CHEMBL3103349 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20IN3O2 |
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| Mol. Mass. | 401.2427 |
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| SMILES | Ic1ccc(cc1)N1CCN(CC1)C(=O)N1CCOCC1 |
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| Structure | 
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