| Reaction Details |
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 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 1 |
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| Ligand | BDBM27500 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1288125 (CHEMBL3110585) |
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| IC50 | 300±n/a nM |
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| Citation |  Haikarainen, T; Narwal, M; Joensuu, P; Lehtiö, L Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors. ACS Med Chem Lett5:18-22 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly [ADP-ribose] polymerase 1 |
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| Name: | Poly [ADP-ribose] polymerase 1 |
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| Synonyms: | ADPRT | PARP1 | PARP1_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 113518.81 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_1288125 |
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| Residue: | 1016 |
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| Sequence: | MAESSDKLYRVEYAKSGRASCKKCKESIPKDSIRMAFMVESPMFDGKIPHWYHLSCFWKV
GFSIWHPDVEVEGFSELRWDDQQTIKKMAETGGRTDVSGKGQDGVGSKTEKTLIDFGAGY
AKSNRSTCKSCMEKIDKGQVRLSKKVVYPDKPQLGMVDCWYHPKCFVQKREELGFRPEFS
ATHLMGFSVLTAEDQETLKKQLPAIKGERKRKGDEVDGIDEVTKKKSKKEKDKEIKLEKA
LKAQNDLIWNVKDELKKACSTNDLKELLIFNKQEVPSGESAILDRVADGMVFGALLPCEE
CSGQLVFKGDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYFKKLKIKKQDRIF
PPESSTPVGAAAPPSAASAPAAVHSGPPDKPLSNMKILTLGKLSQNKDEVKATIEKLGGK
LTGTANKASLCISTKKEVDKLNKKMEEVKEANIRVVSEDFLQDISASTKSLQELLSTHLL
SPWGAEVKVEPVEAVGPKGKSGAAPSKKSKGPVKEEGTNKSEKRMKLTLKGGAAVDPDSG
LEHNAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKESRYWIFRSWGRVGTVIGS
NKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKHPKKFYPLEIDYGQDEEAVKKLTVN
PGTKSKLPKPVQNLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQ
ALSQGSSDSHILDLSNRFYTLIPHDFGMKKPPLLNNANSVQAKVEMLDNLLDIEVAYSLL
RGGSDDSSKDPIDVNYEKLKTDIKVVDKDSEEAEIIRKYVKNTHATTHNAYDLEVVDIFK
IEREGESQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFA
DMVSKSANYCHTSQGDPIGLILLGEAALGNMYELKHARHISKLPKGKHSVKGLGKTTPDP
SASITVDGVEVPLGTGISSGVNDTCLLYNEYIVYDIAQVHLKYLLKLKFNFKTSLW
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| BDBM27500 |
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| n/a |
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| Name | BDBM27500 |
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| Synonyms: | 5,6-dihydrophenanthridin-6-one | 5H-Phenanthridin-6-one | 5H-Phenanthridin-6-one (PTD) | 6-(5H)-Phenanthridinone | CHEMBL45245 | PND | Phenanthridone | phenanthridin-6(5H)-one |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9NO |
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| Mol. Mass. | 195.2167 |
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| SMILES | O=c1[nH]c2ccccc2c2ccccc12 |
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| Structure | 
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