| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 1 |
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| Ligand | BDBM50446344 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1286966 (CHEMBL3111131) |
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| Ki | 20±n/a nM |
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| Citation |  Chelliah, MV; Chackalamannil, S; Xia, Y; Greenlee, WJ; Ahn, HS; Kurowski, S; Boykow, G; Hsieh, Y; Chintala, M Himbacine-derived thrombin receptor antagonists: c7-aminomethyl and c9a-hydroxy analogues of vorapaxar. ACS Med Chem Lett5:183-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 1 |
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| Name: | Proteinase-activated receptor 1 |
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| Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
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| Type: | Protein |
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| Mol. Mass.: | 47450.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25116 |
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| Residue: | 425 |
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| Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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| BDBM50446344 |
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| n/a |
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| Name | BDBM50446344 |
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| Synonyms: | CHEMBL3109578 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33FN2O5 |
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| Mol. Mass. | 508.5811 |
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| SMILES | CCOC(=O)N[C@@H]1CC[C@@H]2[C@@H](C1)C[C@]1(O)[C@@H]([C@@H](C)OC1=O)[C@H]2C=Cc1ccc(cn1)-c1cccc(F)c1 |r,w:23.26| |
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| Structure | 
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