| Reaction Details |
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 | Report a problem with these data |
| Target | Vitamin D3 receptor |
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| Ligand | BDBM50446371 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1287003 (CHEMBL3111314) |
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| IC50 | 2200±n/a nM |
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| Citation |  Sidhu, PS; Nassif, N; McCallum, MM; Teske, K; Feleke, B; Yuan, NY; Nandhikonda, P; Cook, JM; Singh, RK; Bikle, DD; Arnold, LA Development of novel Vitamin D Receptor-Coactivator Inhibitors. ACS Med Chem Lett5:199-204 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vitamin D3 receptor |
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| Name: | Vitamin D3 receptor |
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| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 48288.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11473 |
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| Residue: | 427 |
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| Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
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| BDBM50446371 |
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| n/a |
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| Name | BDBM50446371 |
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| Synonyms: | CHEMBL3109597 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23F3N2O3 |
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| Mol. Mass. | 456.4569 |
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| SMILES | COc1ccc(NC(c2c(C)[nH]c3ccccc23)c2ccc(OC(F)(F)F)cc2)cc1OC |
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| Structure | 
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