| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
|---|
| Ligand | BDBM50446753 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1288411 (CHEMBL3118263) |
|---|
| IC50 | 6.6±n/a nM |
|---|
| Citation |  Takai, K; Nakajima, T; Takanashi, Y; Sone, T; Nariai, T; Chiyo, N; Nakatani, S; Ishikawa, C; Yamaguchi, N; Fujita, K; Yamada, K Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action. Bioorg Med Chem22:1548-57 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional epoxide hydrolase 2 |
|---|
| Name: | Bifunctional epoxide hydrolase 2 |
|---|
| Synonyms: | Ephx2 | Epoxide hydrolase 2 | HYES_RAT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 62337.15 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1465995 |
|---|
| Residue: | 554 |
|---|
| Sequence: | MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
|
|
|
|---|
| BDBM50446753 |
|---|
| n/a |
|---|
| Name | BDBM50446753 |
|---|
| Synonyms: | CHEMBL3114610 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25ClN2O4 |
|---|
| Mol. Mass. | 428.909 |
|---|
| SMILES | OC(=O)Cc1ccc(OC2CCN(CC2)C(=O)N[C@H]2C[C@@H]2c2ccccc2)c(Cl)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
