Reaction Details |
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Target | Bifunctional epoxide hydrolase 2 |
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Ligand | BDBM50446768 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1288411 (CHEMBL3118263) |
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IC50 | 3.2±n/a nM |
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Citation | Takai, K; Nakajima, T; Takanashi, Y; Sone, T; Nariai, T; Chiyo, N; Nakatani, S; Ishikawa, C; Yamaguchi, N; Fujita, K; Yamada, K Structure-based optimization of cyclopropyl urea derivatives as potent soluble epoxide hydrolase inhibitors for potential decrease of renal injury without hypotensive action. Bioorg Med Chem22:1548-57 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional epoxide hydrolase 2 |
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Name: | Bifunctional epoxide hydrolase 2 |
Synonyms: | Ephx2 | Epoxide hydrolase 2 | HYES_RAT |
Type: | PROTEIN |
Mol. Mass.: | 62337.15 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1465995 |
Residue: | 554 |
Sequence: | MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
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BDBM50446768 |
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n/a |
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Name | BDBM50446768 |
Synonyms: | CHEMBL3114595 |
Type | Small organic molecule |
Emp. Form. | C22H23F3N2O2 |
Mol. Mass. | 404.4254 |
SMILES | FC(F)(F)c1ccccc1OC1CCN(CC1)C(=O)N[C@H]1C[C@@H]1c1ccccc1 |r| |
Structure |
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