| Reaction Details |
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 | Report a problem with these data |
| Target | Neuroendocrine convertase 2 |
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| Ligand | BDBM50446944 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1290738 (CHEMBL3117750) |
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| Ki | 0.240000±n/a nM |
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| Citation |  Kwiatkowska, A; Couture, F; Levesque, C; Ly, K; Desjardins, R; Beauchemin, S; Prahl, A; Lammek, B; Neugebauer, W; Dory, YL; Day, R Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem57:98-109 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuroendocrine convertase 2 |
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| Name: | Neuroendocrine convertase 2 |
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| Synonyms: | KEX2-like endoprotease 2 | NEC 2 | NEC2 | NEC2_HUMAN | Neuroendocrine convertase 2 | PC2 | PCSK2 | Prohormone convertase 2 | Proprotein convertase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70563.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290738 |
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| Residue: | 638 |
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| Sequence: | MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
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| BDBM50446944 |
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| n/a |
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| Name | BDBM50446944 |
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| Synonyms: | CHEMBL3115771 |
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| Type | Small organic molecule |
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| Emp. Form. | C51H90N14O8 |
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| Mol. Mass. | 1027.3493 |
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| SMILES | [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(cc1)-[#6](-[#7])=[#7] |r| |
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| Structure | 
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