| Reaction Details |
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 | Report a problem with these data |
| Target | Proprotein convertase subtilisin/kexin type 7 |
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| Ligand | BDBM50446945 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1290739 (CHEMBL3117751) |
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| Ki | 72±n/a nM |
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| Citation |  Kwiatkowska, A; Couture, F; Levesque, C; Ly, K; Desjardins, R; Beauchemin, S; Prahl, A; Lammek, B; Neugebauer, W; Dory, YL; Day, R Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem57:98-109 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proprotein convertase subtilisin/kexin type 7 |
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| Name: | Proprotein convertase subtilisin/kexin type 7 |
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| Synonyms: | LPC | Lymphoma proprotein convertase | PC7 | PC8 | PCSK7 | PCSK7_HUMAN | Prohormone convertase PC7 | Proprotein convertase PC7 | Proprotein convertase subtilisin/kexin type 7 | SPC7 | Subtilisin/kexin type 7 | Subtilisin/kexin-like protease PC7 | hPC8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86233.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290739 |
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| Residue: | 785 |
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| Sequence: | MPKGRQKVPHLDAPLGLPTCLWLELAGLFLLVPWVMGLAGTGGPDGQGTGGPSWAVHLES
LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLFVQPAGHRPALEVEAIRQQVEAV
LAGHEAVRWHSEQRLLRRAKRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRG
VTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVP
NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGP
HQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRM
PFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALML
QVRPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWT
SVPYLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRG
SLELKLFCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESF
QVGILRQWQLTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTI
TPNTLKTLVLVGCFTVFWTVYYMLEVYLSQRNVASNQVCRSGPCHWPHRSRKAKEEGTEL
ESVPLCSSKDPDEVETESRGPPTTSDLLAPDLLEQGDWSLSQNKSALDCPHQHLDVPHGK
EEQIC
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| BDBM50446945 |
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| n/a |
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| Name | BDBM50446945 |
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| Synonyms: | CHEMBL3115770 |
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| Type | Small organic molecule |
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| Emp. Form. | C48H91N15O8 |
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| Mol. Mass. | 1006.3318 |
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| SMILES | [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]\[#6]=[#6]\[#6]\[#7]=[#6](/[#7])-[#7] |r| |
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| Structure | 
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