| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-acyl carrier reductase ENR |
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| Ligand | BDBM50447260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1290812 (CHEMBL3118190) |
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| IC50 | >1000±n/a nM |
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| Citation |  Wilkinson, C; McPhillie, MJ; Zhou, Y; Woods, S; Afanador, GA; Rawson, S; Khaliq, F; Prigge, ST; Roberts, CW; Rice, DW; McLeod, R; Fishwick, CW; Muench, SP The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target. Bioorg Med Chem Lett24:911-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-acyl carrier reductase ENR |
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| Name: | Enoyl-acyl carrier reductase ENR |
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| Synonyms: | Enoyl-acyl carrier reductase | Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43663.67 |
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| Organism: | Toxoplasma gondii |
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| Description: | ChEMBL_1290812 |
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| Residue: | 417 |
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| Sequence: | MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSS
SSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVA
DSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYP
LDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPL
LETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKA
ALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLR
RDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
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| BDBM50447260 |
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| n/a |
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| Name | BDBM50447260 |
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| Synonyms: | CHEMBL2270735 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N2 |
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| Mol. Mass. | 250.3382 |
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| SMILES | Cc1ccc(Cn2cnc3cc(C)c(C)cc23)cc1 |
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| Structure | 
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