| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50447263 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1291251 (CHEMBL3117036) |
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| IC50 | 87±n/a nM |
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| Citation |  St Jean, DJ; Ashton, KS; Bartberger, MD; Chen, J; Chmait, S; Cupples, R; Galbreath, E; Helmering, J; Hong, FT; Jordan, SR; Liu, L; Kunz, RK; Michelsen, K; Nishimura, N; Pennington, LD; Poon, SF; Reid, D; Sivits, G; Stec, MM; Tadesse, S; Tamayo, N; Van, G; Yang, KC; Zhang, J; Norman, MH; Fotsch, C; Lloyd, DJ; Hale, C Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. J Med Chem57:325-38 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50447263 |
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| n/a |
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| Name | BDBM50447263 |
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| Synonyms: | CHEMBL3114000 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F6N4O3S |
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| Mol. Mass. | 484.416 |
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| SMILES | Nc1ccc(cn1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F |
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| Structure | 
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