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TargetHexokinase-4
LigandBDBM50447270
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1291068 (CHEMBL3119630)
EC50 1190±n/a nM
Citation St Jean, DJAshton, KSBartberger, MDChen, JChmait, SCupples, RGalbreath, EHelmering, JHong, FTJordan, SRLiu, LKunz, RKMichelsen, KNishimura, NPennington, LDPoon, SFReid, DSivits, GStec, MMTadesse, STamayo, NVan, GYang, KCZhang, JNorman, MHFotsch, CLloyd, DJHale, C Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles. J Med Chem57:325-38 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hexokinase-4
Name:Hexokinase-4
Synonyms:Gck | Gk | Glucokinase | HK IV | HK4 | HXK4_MOUSE | Hexokinase-4 | Hexokinase-D
Type:Enzyme
Mol. Mass.:52075.40
Organism:Mus musculus (Mouse)
Description:P52792
Residue:465
Sequence:
MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGE
LVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLRPS
VADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50447270
n/a
NameBDBM50447270
Synonyms:CHEMBL3113988
TypeSmall organic molecule
Emp. Form.C24H30F3N3O5S2
Mol. Mass.561.637
SMILESC[C@@](O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1[C@@H]2C[C@@H](O)[C@H]1COC2)S(=O)(=O)c1cccs1)C(F)(F)F |r,THB:15:16:18.19:24.22.23,20:19:16:24.22.23|
Structure
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