| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Ligand | BDBM50447996 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1288772 (CHEMBL3116693) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Sheffler, DJ; Nedelovych, MT; Williams, R; Turner, SC; Duerk, BB; Robbins, MR; Jadhav, SB; Niswender, CM; Jones, CK; Conn, PJ; Daniels, RN; Lindsley, CW Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres. Bioorg Med Chem Lett24:1062-6 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Name: | Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 87438.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
|---|
| Residue: | 797 |
|---|
| Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
|
|
|
|---|
| BDBM50447996 |
|---|
| n/a |
|---|
| Name | BDBM50447996 |
|---|
| Synonyms: | CHEMBL3115209 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19Cl2N5O3S |
|---|
| Mol. Mass. | 480.368 |
|---|
| SMILES | Cn1cnc(c1)S(=O)(=O)N1CC(C1)C(NC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
