Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50448052 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1289501 (CHEMBL3117417) |
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IC50 | 4.0±n/a nM |
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Citation | El-Subbagh, HI; Hassan, GS; El-Messery, SM; Al-Rashood, ST; Al-Omary, FA; Abulfadl, YS; Shabayek, MI Nonclassical antifolates, part 5. Benzodiazepine analogs as a new class of DHFR inhibitors: synthesis, antitumor testing and molecular modeling study. Eur J Med Chem74:234-45 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) |
Type: | Enzyme |
Mol. Mass.: | 21603.71 |
Organism: | Bos taurus (Cattle) |
Description: | P00376 |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
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BDBM50448052 |
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n/a |
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Name | BDBM50448052 |
Synonyms: | CHEMBL3115740 |
Type | Small organic molecule |
Emp. Form. | C32H34N2O4 |
Mol. Mass. | 510.6234 |
SMILES | COc1ccc(C=C2CCCC3C2=Nc2cc(C)c(C)cc2N=C3c2ccc(OC)c(OC)c2)cc1OC |w:6.5,c:24,t:13| |
Structure |
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