| Reaction Details |
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 | Report a problem with these data |
| Target | Fatty-acid amide hydrolase 1 [30-579] |
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| Ligand | BDBM50350557 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1293852 (CHEMBL3123528) |
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| IC50 | 3.0±n/a nM |
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| Citation |  Keith, JM; Hawryluk, N; Apodaca, RL; Chambers, A; Pierce, JM; Seierstad, M; Palmer, JA; Webb, M; Karbarz, MJ; Scott, BP; Wilson, SJ; Luo, L; Wennerholm, ML; Chang, L; Rizzolio, M; Chaplan, SR; Breitenbucher, JG 1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett24:1280-4 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fatty-acid amide hydrolase 1 [30-579] |
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| Name: | Fatty-acid amide hydrolase 1 [30-579] |
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| Synonyms: | Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1 |
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| Type: | Single-pass membrane protein; homodimer |
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| Mol. Mass.: | 60474.00 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P97612 (aa 30-579) |
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| Residue: | 550 |
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| Sequence: | RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSG
ELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKG
HDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWK
SSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGC
VYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGY
YETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFL
QNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQH
EIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPV
TTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVE
QLMTPQKQPS
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| BDBM50350557 |
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| n/a |
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| Name | BDBM50350557 |
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| Synonyms: | CHEMBL1812715 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20ClN3O2 |
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| Mol. Mass. | 369.845 |
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| SMILES | CCOc1ccc(cc1Cl)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| |
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| Structure | 
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