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TargetDihydrofolate reductase
LigandBDBM50448367
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1294109
Ki 5000±n/a nM
Citation Piras SCarta ABriguglio ICorona PPaglietti GLuciani RCosti MPFerrari S 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes. Eur J Med Chem 75:169-83 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50448367
n/a
NameBDBM50448367
Synonyms:CHEMBL3121458
TypeSmall organic molecule
Emp. Form.C23H17ClF3N3
Mol. Mass.427.849
SMILESCN(Cc1nc2cc(ccc2nc1-c1ccccc1)C(F)(F)F)c1ccc(Cl)cc1
Structure
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