| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucokinase regulatory protein |
|---|
| Ligand | BDBM50448562 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1296099 (CHEMBL3131528) |
|---|
| IC50 | 36±n/a nM |
|---|
| Citation |  Ashton, KS; Andrews, KL; Bryan, MC; Bryan, MC; Chen, J; Chen, K; Chen, M; Chmait, S; Croghan, M; Cupples, R; Fotsch, C; Helmering, J; Jordan, SR; Kurzeja, RJ; Michelsen, K; Pennington, LD; Poon, SF; Sivits, G; Van, G; Vonderfecht, SL; Wahl, RC; Zhang, J; Lloyd, DJ; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept. J Med Chem57:309-24 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glucokinase regulatory protein |
|---|
| Name: | Glucokinase regulatory protein |
|---|
| Synonyms: | GCKR | GCKR_HUMAN | GKRP | Glucokinase regulator |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 68685.97 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_103091 |
|---|
| Residue: | 625 |
|---|
| Sequence: | MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI
FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV
GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ
KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE
RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV
RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ
TIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL
STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR
AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA
VRSALAGPGQKRTADPLEILEPDVQ
|
|
|
|---|
| BDBM50448562 |
|---|
| n/a |
|---|
| Name | BDBM50448562 |
|---|
| Synonyms: | CHEMBL3127348 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25F6N3O4S2 |
|---|
| Mol. Mass. | 573.572 |
|---|
| SMILES | OC(c1ccc(cc1)N1CCN(C[C@@H]1CN1CCOCC1)S(=O)(=O)c1cccs1)(C(F)(F)F)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
