| Reaction Details |
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 | Report a problem with these data |
| Target | Glucokinase regulatory protein |
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| Ligand | BDBM50448574 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1296099 (CHEMBL3131528) |
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| IC50 | 5340±n/a nM |
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| Citation |  Ashton, KS; Andrews, KL; Bryan, MC; Bryan, MC; Chen, J; Chen, K; Chen, M; Chmait, S; Croghan, M; Cupples, R; Fotsch, C; Helmering, J; Jordan, SR; Kurzeja, RJ; Michelsen, K; Pennington, LD; Poon, SF; Sivits, G; Van, G; Vonderfecht, SL; Wahl, RC; Zhang, J; Lloyd, DJ; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept. J Med Chem57:309-24 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucokinase regulatory protein |
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| Name: | Glucokinase regulatory protein |
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| Synonyms: | GCKR | GCKR_HUMAN | GKRP | Glucokinase regulator |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68685.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103091 |
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| Residue: | 625 |
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| Sequence: | MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEI
FQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISV
GLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQ
KAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFE
RAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV
RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQ
TIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQREL
STKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLR
AIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEA
VRSALAGPGQKRTADPLEILEPDVQ
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| BDBM50448574 |
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| n/a |
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| Name | BDBM50448574 |
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| Synonyms: | CHEMBL3127358 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22F6N2O3S2 |
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| Mol. Mass. | 516.521 |
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| SMILES | CC(C)[C@H]1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccs1 |r| |
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| Structure | 
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