| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase delta catalytic subunit |
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| Ligand | BDBM50448691 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1297313 (CHEMBL3132278) |
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| IC50 | >200000±n/a nM |
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| Citation |  Mizushina, Y; Suzuki-Fukudome, H; Takeuchi, T; Takemoto, K; Kuriyama, I; Yoshida, H; Kamisuki, S; Sugawara, F Formosusin A, a novel specific inhibitor of mammalian DNA polymeraseß from the fungus Paecilomyces formosus. Bioorg Med Chem22:1070-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase delta catalytic subunit |
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| Name: | DNA polymerase delta catalytic subunit |
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| Synonyms: | DNApol-delta | DNApolD1 | DPOD1_DROME | PolD | PolD1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 124909.55 |
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| Organism: | Drosophila melanogaster |
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| Description: | ChEMBL_108050 |
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| Residue: | 1092 |
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| Sequence: | MDGKRKFNGTSNGHAKKPRNPDDDEEMGFEAELAAFENSEDMDQTLLMGDGPENQTTSER
WSRPPPPELDPSKHNLEFQQLDVENYLGQPLPGMPGAQIGPVPVVRMFGVTMEGNSVCCH
VHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIHG
YNGDKKQRYIKISVTLPRFVAAASRLLKKEVIMSEIDFQDCRAFENNIDFDIRFMVDTDV
VGCNWIELPMGHWRIRNSHSKPLPESRCQIEVDVAFDRFISHEPEGEWSKVAPFRILSFD
IECAGRKGIFPEAKIDPVIQIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCHDKETQ
MLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQML
QSKQMGRRENQYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSIITD
LQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQIKVL
SQLLRKAKTKGFIMPSYTSQGSDEQYEGATVIEPKRGYYADPISTLDFASLYPSIMMAHN
LCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGLLPEILESLLAARKRAK
NDLKVETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMT
KNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSKFVHPIK
LEFEKVYYPYLLINKKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLVANLMNSCLQKLL
IERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTDYAAKQAHVELAAKMKKRDPGT
APKLGDRVPYVICAAAKNTPAYQKAEDPLYVLENSVPIDATYYLEQQLSKPLLRIFEPIL
GDNAESILLKGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGYEQACLCPHCEPR
MSELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDCPIFYMRQKVRMDLDNQ
EKRVLRFGLAEW
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| BDBM50448691 |
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| n/a |
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| Name | BDBM50448691 |
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| Synonyms: | CHEMBL3127729 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H25NO3 |
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| Mol. Mass. | 291.3853 |
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| SMILES | C\C(\C=C\CCC(=O)N1CCCC1=O)=C/C1CCCCO1 |
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| Structure | 
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