| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase alpha catalytic subunit |
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| Ligand | BDBM50448689 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1297314 (CHEMBL3132279) |
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| IC50 | >200000±n/a nM |
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| Citation |  Mizushina, Y; Suzuki-Fukudome, H; Takeuchi, T; Takemoto, K; Kuriyama, I; Yoshida, H; Kamisuki, S; Sugawara, F Formosusin A, a novel specific inhibitor of mammalian DNA polymeraseß from the fungus Paecilomyces formosus. Bioorg Med Chem22:1070-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase alpha catalytic subunit |
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| Name: | DNA polymerase alpha catalytic subunit |
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| Synonyms: | DNApol-alpha | DNApol-alpha180 | DPOLA_DROME | POLA | PolA1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 169924.17 |
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| Organism: | Drosophila melanogaster |
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| Description: | ChEMBL_1297314 |
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| Residue: | 1488 |
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| Sequence: | MSESPSEPRAKRQRVDKNGRFAAMERLRQLKGTKNKCKVEDQVDDVYDVVDEREYAKRAQ
EKYGDDWIEEDGTGYAEDLRDFFEDEDEYSDGEEDRKDSKKKKGVAPNSKKRPRENEKPV
TGKASIKNLFSNAVPKKMDVKTSVKDDDILADILGEIKEEPAATSEKAEKVIAPAKISVT
SRKFDAAAAKEYMNSFLNNIKVQEQERKKAEASSDNEMLERILKPKAAVPNTKVAFFSSP
TIKKEPMPEKTPAKKATEDPFSDNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTS
QSKVAEKSAPKKETTGSPKESESEDISRLLNNWESICQMDDDFEKSVLTTEQDSTISSDQ
QLRFWYWEAYEDPVKMPGEVFLFGRTADGKSVCLRVQNINRVLYLLPRQFLLDPISKEPT
KQKVTVADIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIGIEVPQSCDYLEVHYDGKKP
LPNLSADKKYNSIAHIFGATTNALERFLLDRKIKGPCWLQVTGFKVSPTPMSWCNTEVTL
TEPKNVELVQDKGKPAPPPPLTLLSLNVRTSMNPKTSRNEICMISMLTHNRFHIDRPAPQ
PAFNRHMCALTRPAVVSWPLDLNFEMAKYKSTTVHKHDSERALLSWFLAQYQKIDADLIV
TFDSMDCQLNVITDQIVALKIPQWSRMGRLRLSQSFGKRLLEHFVGRMVCDVKRSAEECI
RARSYDLQTLCKQVLKLKESERMEVNADDLLEMYEKGESITKLISLTMQDNSYLLRLMCE
LNIMPLALQITNICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPDKKPVSKRSGAGDT
DATLSGADATMQTKKKAAYAGGLVLEPMRGLYEKYVLLMDFNSLYPSIIQEYNICFTTVQ
QPVDADELPTLPDSKTEPGILPLQLKRLVESRKEVKKLMAAPDLSPELQMQYHIRQMALK
LTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQKMNYDVVYGDTDSLMINT
NITDYDQVYKIGHNIKQSVNKLYKQLELDIDGVFGCLLLLKKKKYAAIKLSKDSKGNLRR
EQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHAQLEKIKTQIAEGVVPL
PLFVITKQLTRTPQEYANSASLPHVQVALRMNRERNRRYKKGDMVDYVICLDGTTNAAMQ
RAYHLDELKTSEDKKLQLDTNYYLGHQIHPVVTRMVEVLEGTDASRIAECLGMDPTKFRQ
NAQRTQRENTEQSEGESLLKTTLQLYRLCEPFRFQCVTCKTEQLMASAYRPGPSNSHIAV
LQQCAKSECQTAPIQYLASVRNQLQLSMRQYVQRFYKNWLVCDHPDCNFNTRTHSLRKKS
HRPLCQKCRSGSLLRQYTERDLYNQLCYLRFMFDLGKQTLQQKPTLTPELEQAYQLLYET
VDQQLQSSSYVIISLSKLFARSLAQMSLQPSVAQPQIEAIPSALADVV
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| BDBM50448689 |
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| n/a |
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| Name | BDBM50448689 |
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| Synonyms: | CHEMBL3127730 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H25NO3 |
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| Mol. Mass. | 291.3853 |
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| SMILES | CCCC[C@@H](O)\C=C(/C)\C=C\C=C/C(=O)N1CCCC1=O |r| |
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| Structure | 
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