| Reaction Details |
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 | Report a problem with these data |
| Target | Neutral cholesterol ester hydrolase 1 |
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| Ligand | BDBM50448892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1296364 (CHEMBL3129774) |
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| IC50 | >100000±n/a nM |
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| Citation |  Otrubova, K; Cravatt, BF; Boger, DL Design, synthesis, and characterization ofa-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase. J Med Chem57:1079-89 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutral cholesterol ester hydrolase 1 |
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| Name: | Neutral cholesterol ester hydrolase 1 |
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| Synonyms: | Aadacl1 | Arylacetamide deacetylase-like 1 | CPO-BP | Chlorpyrifos oxon-binding protein | Kiaa1363 | NCEH | NCEH1_MOUSE | Nceh1 | Neutral cholesterol ester hydrolase |
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| Type: | Single-pass type II membrane protein; hydrolase |
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| Mol. Mass.: | 45742.11 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Assays were using membranes of recombinant KIAA1363 transiently transfected in COS-7 cells. |
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| Residue: | 408 |
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| Sequence: | MRSSCVLLAALLALAAYYVYIPLPSAVSDPWKLMLLDATFRGAQQVSNLIHSLGLNHHLI
ALNFIITSFGKQSARSSPKVKVTDTDFDGVEVRVFEGSPKPEEPLRRSVIYIHGGGWALA
SAKISYYDQLCTTMAEELNAVIVSIEYRLVPQVYFPEQIHDVIRATKYFLQPEVLDKYKV
DPGRVGISGDSAGGNLAAALGQQFTYVASLKNKLKLQALVYPVLQALDFNTPSYQQSMNT
PILPRHVMVRYWLDYFKGNYDFVEAMIVNNHTSLDVERAAALRARLDWTSLLPSSIKKNY
KPIMQTTGNARIVQEIPQLLDAAASPLIAEQEVLEALPKTYILTCEHDVLRDDGIMYAKR
LESAGVNVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
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| BDBM50448892 |
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| n/a |
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| Name | BDBM50448892 |
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| Synonyms: | CHEMBL3125288 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O3S |
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| Mol. Mass. | 422.54 |
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| SMILES | CS(=O)C=Cc1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1 |w:3.2| |
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| Structure | 
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