| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 2 |
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| Ligand | BDBM50033369 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_836107 (CHEMBL2077543) |
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| IC50 | 210000±n/a nM |
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| Citation |  Goralski, KB; Lou, G; Prowse, MT; Gorboulev, V; Volk, C; Koepsell, H; Sitar, DS The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther303:959-68 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 2 |
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| Name: | Solute carrier family 22 member 2 |
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| Synonyms: | Adrenaline alpha2 | Oct2 | Organic cation transporter 2 | S22A2_RAT | Slc22a2 | Solute carrier family 22 member 2 | rOCT2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 62348.38 |
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| Organism: | RAT |
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| Description: | Adrenaline alpha2 0 RAT::Q9R0W2 |
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| Residue: | 555 |
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| Sequence: | MSTVDDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPDHHCWSPGAAKLSQ
RCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQLPLG
PCEHGWVYNTPGSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCL
LVTILINAISGALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVGIC
YQIAFTVGLLILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAM
KIIKHIAKKNGKSVPVSLQNLTPDEDAGKKLNPSFLDLVRTPQIRKHTLILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLA
SVFIPDDLQWLKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGII
TPFLVYRLTDIWMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDAENMQRPRKKKE
KRIYLQVKQADRPLS
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| BDBM50033369 |
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| n/a |
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| Name | BDBM50033369 |
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| Synonyms: | AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL |
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| Type | Small organic molecule |
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| Emp. Form. | C10H17N |
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| Mol. Mass. | 151.2487 |
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| SMILES | NC12CC3CC(CC(C3)C1)C2 |THB:6:5:2:8.7.9,6:7:4.5.10:2,9:7:4:10.1.2,9:1:4:8.6.7,0:1:4:8.6.7| |
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| Structure | 
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