| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H2 receptor |
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| Ligand | BDBM50000956 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1333836 (CHEMBL3231654) |
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| EC50 | 19000±n/a nM |
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| Citation |  Bolhofer, WA; Hoffman, JM; Habecker, CN; Pietruszkiewicz, AM; Cragoe, EJ; Torchiana, ML Inhibition of gastric acid secretion by 1,8-naphthyridin-2(1H)-ones. J Med Chem22:301-6 (1979) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H2 receptor |
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| Name: | Histamine H2 receptor |
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| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2_RAT | Hrh2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40269.37 |
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| Organism: | RAT |
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| Description: | HISTAMINE H2 HRH2 RAT::P25102 |
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| Residue: | 358 |
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| Sequence: | MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSL
AATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEV
YGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMG
AFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQ
LFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
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| BDBM50000956 |
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| n/a |
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| Name | BDBM50000956 |
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| Synonyms: | CHEMBL3228818 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H21N3O |
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| Mol. Mass. | 247.336 |
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| SMILES | CN(C)CCN1C(=O)CCc2c(C)cc(C)nc12 |
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| Structure | 
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