Reaction Details |
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Target | DNA gyrase subunit B |
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Ligand | BDBM50006548 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1334838 (CHEMBL3239012) |
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IC50 | 3600±n/a nM |
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Citation | Basarab, GS; Boriack-Sjodin, PA; Illingworth, R; Manchester, JI; Dangel, B; Sriram, S Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents. Cell Chem Biol56:8712-35 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA gyrase subunit B |
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Name: | DNA gyrase subunit B |
Synonyms: | DNA gyrase | DNA gyrase subunit B (DNA gyraseB) | DNA gyrase subunit B (gyrB) | GYRB_STAAU | gyrB |
Type: | Enzyme Subunit |
Mol. Mass.: | 72530.91 |
Organism: | Staphylococcus aureus |
Description: | n/a |
Residue: | 644 |
Sequence: | MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
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BDBM50006548 |
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n/a |
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Name | BDBM50006548 |
Synonyms: | CHEMBL3235071 |
Type | Small organic molecule |
Emp. Form. | C12H12N4O3S |
Mol. Mass. | 292.314 |
SMILES | CCNC(=O)Nc1ccc(cn1)-c1nc(cs1)C(O)=O |
Structure |
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