| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50006568 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1334838 (CHEMBL3239012) |
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| IC50 | <10.0±n/a nM |
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| Citation |  Basarab, GS; Boriack-Sjodin, PA; Illingworth, R; Manchester, JI; Dangel, B; Sriram, S Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents. Cell Chem Biol56:8712-35 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | DNA gyrase | DNA gyrase subunit B (DNA gyraseB) | DNA gyrase subunit B (gyrB) | GYRB_STAAU | gyrB |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 72530.91 |
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| Organism: | Staphylococcus aureus |
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| Description: | n/a |
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| Residue: | 644 |
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| Sequence: | MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
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| BDBM50006568 |
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| n/a |
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| Name | BDBM50006568 |
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| Synonyms: | CHEMBL3235088 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14F3N5O3S2 |
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| Mol. Mass. | 493.482 |
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| SMILES | CCNC(=O)Nc1cc(-c2nc(cs2)C(F)(F)F)c(cn1)-c1nc2cccc(C(O)=O)c2s1 |
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| Structure | 
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