| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50008222 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1339173 (CHEMBL3243336) |
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| IC50 | 717±n/a nM |
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| Citation |  Taddei, M; Ferrini, S; Giannotti, L; Corsi, M; Manetti, F; Giannini, G; Vesci, L; Milazzo, FM; Alloatti, D; Guglielmi, MB; Castorina, M; Cervoni, ML; Barbarino, M; Foderà, R; Carollo, V; Pisano, C; Armaroli, S; Cabri, W Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold. J Med Chem57:2258-74 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50008222 |
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| n/a |
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| Name | BDBM50008222 |
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| Synonyms: | CHEMBL3235118 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H40N6O6 |
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| Mol. Mass. | 580.6752 |
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| SMILES | CC(C)c1cc(c(O)cc1O)-n1nnc(C(=O)NCCCCCCC(=O)NO)c1-c1ccc(CN2CCOCC2)cc1 |
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| Structure | 
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